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Finally the ectoderm, or outer tissue, develops into the integumentary system (the skin) and the nervous system. Lissencephaly shows several genetic inheritance patterns, including hemizygous due to a chromosomal defect, autosomal recessive and X-linked. Rhinorrhea at 2 weeks: meta-analysis of 3 trials–intranasal corticosteroid versus oral leukotriene receptor antagonist. Re-sheathing needles - do not re-sheath or re-cover used needles unless there is a special apparatus which will hold the sheath and give the health worker protection. The epidemiology of this disease is largely determined by: o The species of sandflies, their ecology and behavior; o The availability of a wide range of hosts; 141 o The species and strains of leishmania parasites. It is an endopeptidase that is specifc for peptide linkages formed by carboxyl groups of basic amino acids, namely arginine, lysine. 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